Introduction: How to accelerate the drug development process? What kind of weapon can solve the bottleneck of drug development? How to develop modern new drugs in valuable and abundant natural medicine resources? The proliferation of macromolecules such as monoclonal antibodies, vaccines, and recombinant proteins is exploding. Do you expect to develop new drugs as soon as possible to occupy a place? Molecular Devices offers a complete solution for the most critical steps in the drug development process.

Drug screening is the testing and testing of preliminary pharmacological activities of substances that may be used as medicinal substances. For innovative drugs, screening is an indispensable means and approach. In particular, the competition for contemporary innovative drug research is very intense. The focus of competition lies in the screening of new drugs. Low-cost and high-efficiency screening of new drugs is the core of the problem. It is the process of shortening the discovery of new drugs. Molecular Devices is committed to providing innovative solutions for traditional small molecule and macromolecular drug development. Its products are known in the industry for its high throughput, cost saving, high automation, high stability, easy operation and use, and are recognized by the industry as a leader in high-throughput drug screening technology.

Kinase and membrane transporter drug development and screening

When the human genome was just released more than a decade ago, it was theoretically predicted that there might be more than 500 proteins in the protein in thousands of protein libraries. Among the recognized drug targets, protein kinases have become the second largest class of drug screening targets in the field of drug screening.

Traditional methods for studying kinase, phosphatase, and phosphodiesterase activities are twofold: one is by radioisotope labeling and the other is highly specific antibody labeling; the former has problems with safety and disposal, while the latter has Expensive and time consuming problems. To address these existing issues, Molecular Devices has introduced the patented IMAP® technology, a non-radioactive and homogeneous analysis method based on phosphate group detection. IMAP technology is not based on specific antibody technology, but a general technology platform for the detection of any kinase, phosphatase and phosphodiesterases. In addition, to help researchers select the right kinase substrate, Molecular Devices has also developed the IMAP Substrate Finder Kits to quickly and accurately detect the activity of one or several kinases relative to multiple peptide substrates in a 384-well microplate.

Dysfunction of neurotransmitter transporters is an important cause of neuroinhibition and degenerative diseases, such as the formation of Alzheimer and Parkinson. Fatty acids play important roles in many cellular biological processes, such as mitochondrial oxidation, biofilm synthesis, and energy storage.

Conventional methods for screening neurotransmitter transporters and fatty acid transporters are both isotope labeling and complex fluorescent labeling methods, which may require a low-throughput fluorescence-activated cell sorting process, or require washing to damage cells. Molecular Devices offers two types of kits for researchers in the pharmaceutical field of membrane transporters: the Neurotransmitter Uptake Transporter Kit and the QBTTM Fatty Acid Uptake Transporter Kit. Both kits are homologous, disposable, for live cell fluorescence detection and can be extended to high throughput screening.

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