There are new solutions to the causes of neuronal cell degradation

Release date: 2007-11-05

New causes for neuronal cell degradation Diseases that destroy nerve cells, such as Alzheimer's disease, multiple sclerosis, and sporadic Creutzfeldt-Jakob disease (mad cow disease), are always elusive to scientists and even more difficult to cure. Recently, researchers at the University of Michigan in the United States have discovered a link between an unknown signaling molecule and the health of nerve cells, which is expected to explain the cause of neuronal cell degradation. The research results were published in the recently published Journal of the National Academy of Sciences.
In the study, Professor Louis Eisman and his assistant at the American College of Life Sciences linked this signaling molecule to the massive neuronal degeneration in the brain. This molecule, called PI(3,5)P2 (short for phosphatidylinositol-3,5-diphosphate), is present in all cells and is a very low concentration of lipid.
The signal lipid PI(3,5)P2 is part of a bioinformatics system that not only senses extracellular changes, but also promotes intracellular activity to adapt cells to this change. It is a very unique class of lipids. , bear the special mission of the signal molecule. The lipid-producing enzyme is controlled by the yeast genes FIG4 and VAC14 genes, which are present not only in yeast but also in mice and humans. VAC14 is a gene encoding the PI(3,5)P2 concentration. Wisman found that the nervous system of rats lacking VAC14 was severely degraded, and this degradation appeared to be similar to the degeneration of nerve cells in mice with mutations in FIG4. Once the VAC14 gene was removed, many of the neurons in the body would There is a hollow space and the brain is spongy.
Wisman said that PI(3,5)P2 plays a key role in the survival of nervous system cells. Lower concentrations of PI(3,5)P2 can cause severe neuronal degeneration. This finding indicates that it can be more Good research on the treatment of neurodegenerative diseases such as Alzheimer's disease.

——China Medicine 123 Network

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