According to the UK market intelligence organization's newly published research on the European pharmaceutical packaging market, in the next few years, the initiative of manufacturers may make a big difference in the focus of pharmaceutical packaging. In particular, container packaging will be diverted to cardboard boxes and blister packs, while caps and closures will also have a reduced market share due to reduced container usage. Labels and loose-leaf prints will become even more important.
Market range
It is estimated that the total annual sales of the pharmaceutical packaging materials market in Europe (including Eastern Europe) reached 32.46 {L US dollars. The main packaging form of zui is containers and cardboard boxes, each of which accounts for the total sales, followed by about 22% of the blister packs (including PVC strips and pouches), the rest including bottle seals, labels and many others covering a certain The categories of these drug delivery systems. In terms of materials, paper and board sales accounted for 37%, plastics sales 28%, and metal sales 26% glass sales accounted for only 9%. From now to 2007, sales of packaging materials are expected to grow in parallel with pharmaceutical sales.
Paper packaging material
Paper and cardboard – mainly in the form of cardboard boxes, labels and loose-leaf prints – account for a higher percentage of packaging taxes than other materials (37% in 1998) and are likely to continue to increase over the next few decades. . In addition, pharmaceutical companies are becoming more willing to pay extra for high quality appearance.
Compared with the 2002 level, the market share of paper and board will decline slightly before 2007. This slight fallback does not mean a reduction in sales. Instead, it reflects the contact packaging, ie the container or blister pack, which will have a faster increase. After 2002, the main drivers of paper or board growth (especially the trend toward patient packaging) may no longer exist, and more interest will shift to improving child misuse, vandalism and friendly design for older people. They are mainly concentrated on containers and blister packs rather than cardboard boxes, labels or loose-leaf prints.
The estimated annual consumption of foldable cardboard boxes in Europe is 569 billion, at $0.06 each, equivalent to a market value of 5.4 {g dollars. The use of foldable cartons will increase over the next few decades. The prediction for the next few decades of loose-leaf prints is to maintain the same size, and the increase in the amount is expected to be consistent with the drug.
New regulations in the UK will further increase the cost of loose-leaf prints and labels, and there are no factors that affect sales. In the United States, the appearance of labelled loose-leaf prints may make the outer packaging of the container redundant, and there is no need to add labels to the package. While this approach in Europe may not be as rapid as it is in the United States, it is likely to become more popular. In the United States, container packaging is still more popular than blister packs. The use of labels and loose-leaf prints is unlikely to reduce the amount or cost of packaging used, but simplifying the packaging process reduces its cost.
Measuring material
Plastics account for 28% of European pharmaceutical packaging sales, including containers, caps, closures, blister packs and other packaging forms. In the short to medium term, sales of blister packs will show rapid growth, while replacements for bottled glass are likely to grow later.
The shift from glass to plastic in production containers, including injections and ampoules, has been a trend, but it has been slow to develop. Since the ingredients filtered from plastics can contaminate products, especially liquids, the authorities are trying to manage plastics more carefully. Plastics are slowly replacing glass for packaging syrup. The main reason is that plastic containers often have wide necks, are easier to fill, and are faster to produce on the filling line, not fragile and can provide larger labels. Area to carry more information. The acceptance rate of users is likely to rise only when plastics are properly priced and have better shielding properties than are currently available.
In addition to the fact that plastics do not provide adequate shielding in some products, most of the caps are now made of plastic tape. The aluminum cover is still in use and plastic is unlikely to replace it, which is a problem. Therefore, the growth of plastic caps depends on the increase in drug sales and prices, rather than expecting to replace some form of cap. From a medium- and long-term perspective, it is possible to develop a bottle cap that is friendly to the elderly and prevents children from misusing, thus expanding the market, but for the time being, there are no obvious signs.
Plastic tubes can be used to make small vials, ampoules and suppositories, or to produce hoses for ointments. Among these products, plastics are mainly used in vials and ampoules because they can be produced in a forming-filling-sealing operation with little risk of breakage. Pharmaceutical companies such as Pharmacia - Puqiang have introduced non-destructive plastic vials for the transmission of cytotoxic drugs. It is estimated that 90% of vials and ampoules are still made of glass.
Packaging liquid drugs in plastic often shortens the life of the drug. Due to the relatively weak shielding effect of plastics, there has been no progress in solving this problem in the past, but some new materials, such as cyclic hydrocarbon copolymers, can overcome these difficulties. Polyethylene has better shielding resistance properties than the polymers currently used. Recently, it has carried out stability experiments on this material, although this work is currently only for plastic containers.
The main use of plastic film in pharmaceutical packaging is to form a plastic strip of blister. The development of new materials is making a huge difference in this area, such as the cyclic hydrocarbon copolymer film, which has a more transparent, better shielding effect and can reduce the weight (without the current multilayer film and coating to form a shield). Another potential use for plastic films is in the production of shrink sleeves to protect glass bottles and provide good graphic quality, especially for terephthalic acid polyethylene. The sleeve can be extended all the way to the cap or a breakage seal can be used at the same time. The potential market for shrink sleeves is likely to be limited by the decline of glass in the pharmaceutical industry, and its potential use is likely to be for liquids containing ethanol, because glass provides complete packaging shielding while plastics prevent damage.
Blister packs have good adaptability and appearance and provide an effective solution for many small and difficult packaging products. There is an increasing demand for heat-sealable devices that are simple in structure and quick to retrofit, and a variety of options have emerged, including robot-based intelligent aluminum-plastic packaging systems that meet FDA requirements.
Glass products account for 9% of annual sales. The trend in packaging is having a complex impact on the glass industry, as glass is seen as a packaging material for containers that is of higher quality than plastic. For pharmaceutical manufacturers, the image is becoming a more important aspect. Instead, this trend is transforming containers into blister packs. Although this trend is slow, it is likely to increase the pace. Especially in countries like the UK, pharmacists have traditionally repackaged tablets into bottles, and this operation will be banned. As mentioned earlier, the bottles used to repackage tablets are now often plastic.
The overall impact of the use of packaging management regulations on glass sales will result in a reduction in usage in the short term and a further slight decline in 2007. However, the solid product core will still be glass-packed for 10 years, not only because of its quality, but also because there is no room for choice for some drugs. It is estimated that the European pharmaceutical industry uses 1.3 billion glass bottles a year, at a cost of $0.08 each, and the cost will be $100 million a year. There are many trends in the use of glass in hazardous packaging bottles on the market, especially in the initial actions of packaging. Even in the case of glass that cannot be challenged (such as the packaging of cough syrup), some pharmaceutical companies are beginning to accept the short-lived period of the product and have acquired the benefits of plastic packaging.
Glass tubes can be used to produce ampoules, vials and syringes. In fact, only 5% of these products are made of other materials that are not glass. This has become the main market for the glass industry and has taken a large part in quantity and value. With the development of many recombinant DNA products that can only be administered by non-oral routes, the production of ampoules and vials began to grow. However, with the development of powder and liquid needleless injection systems, the use of conventional syringes has declined.
There will be no progress in the type and use of glass, but competitive methods of delivering drugs can reduce the number and type of injections, especially in Europe, including nasal sprays, inhalants, oral forms (usually Enteric coatings, transdermal patches and needle-free injection delivery systems can affect glass sales.
Metal can be used for containers (especially aerosols), collapsible tubes, needles, caps, bottle closures, aluminum foils and pouches in blister packs. Although metal packaging is relatively expensive, the use of metal (mainly aluminum) is unlikely to fall in the near future. Metal is the only material that can actually withstand stress. The trend of plastics for caps and closures has evolved to the extent that they should be, and the popularity of plastics on collapsible tubes should increase.
It is expected that the incidence of asthma will continue to increase in the next 10 years, and the pharmaceutical industry will use more aerosols. The use of pressure vessels will increase significantly in the next 10 years. This depends on the level of development of the needle-free injection system. This is a technique that uses compressed helium or air to push the drug through the skin, and the further increase in the application of this technique reduces the amount of needle used. If this technology is popular, the total amount of metal used may decline rather than rise.
Metal foil and holographic technology are expected to increase the use of metals in pharmaceutical packaging due to the introduction of various methods of vandalism, theft prevention and piracy. Although there is not much room for mass use, overall, the amount of metal will increase slightly. There is still an unresolved problem in the use of aluminum foil as the bottom seal of the blister pack. It reduces the recyclability of packaging materials and the all-plastic packaging that has been developed is also available. On the other hand, it provides better shielding than plastic and makes the patient more convenient to use. Full metal packaging is still an option, and it can be used to package larger or fragile tablets, although it is a more expensive one; it is well suited to meet the requirements of environmentally friendly packaging.
In short, the amount of metal used, especially aluminum as part of the blister packaging material, is not likely to be reduced.
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